U.S. and Colossal Biosciences to sequence genomes of every endangered species

The United States and Colossal Biosciences are launching a joint initiative to sequence the genomes of every endangered species on the planet, a project that will also establish a genomic and cellular BioVault for long-term conservation. The effort, announced on 25 June 2026, marks the first systematic attempt to decode the genetic blueprints of all 15,000 threatened species listed by the International Union for Conservation of Nature (IUCN), with tissue samples to be biobanked for future de-extinction and medical research.
Colossal Biosciences, the biotech firm behind the woolly mammoth de-extinction project, will lead the sequencing work, while the U.S. government will fund and operate the BioVault, a secure repository designed to preserve viable cells and genetic material indefinitely. “This is not just about saving species from extinction—it’s about creating a living archive of Earth’s biodiversity,” said Dr. George Church, co-founder of Colossal Biosciences and a professor at Harvard Medical School. The BioVault will be housed at a federally designated facility in Colorado, with construction slated for completion in 2027.
The initiative responds to a sharp decline in global biodiversity, with one million species now at risk of extinction within decades. Keytruda, a cancer immunotherapy drug, remains Austria’s single largest medication expense, costing €6,800 per 200-milligram dose without discounts , underscoring the financial strain on health systems even as conservation efforts expand. Meanwhile, Estonia is considering broader coverage for a weight-management drug originally developed for Type 2 diabetes, pending a cost-benefit analysis due this fall .
Scientists involved in the genome project argue that the data will unlock new avenues for conservation, from identifying disease-resistant traits in endangered populations to enabling assisted evolution. “We’re moving from crisis response to proactive genetic stewardship,” said Dr. Beth Shapiro, a paleogeneticist at the University of California, Santa Cruz, and a scientific advisor to the project. The first batch of genomes—covering 500 critically endangered species—is expected to be published by December 2026.
Critics, however, question the project’s feasibility and cost, estimated at $500 million over five years. “Sequencing every endangered species is a monumental task, and the BioVault’s long-term viability depends on sustained funding,” said Dr. Jane Goodall, a conservationist and UN Messenger of Peace. Supporters counter that the investment pales in comparison to the economic value of ecosystem services, which the UN values at $125 trillion annually.
The project aligns with broader global commitments, including the Kunming-Montreal Global Biodiversity Framework, which aims to protect 30% of Earth’s land and water by 2030. As sequencing begins this summer, conservationists hope the initiative will serve as a model for international collaboration in the face of accelerating biodiversity loss.
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